MEN1 gene mutation is associated with tumors in which glands?

MEN1 gene mutation is associated with tumors in which glands?

• A. Pituitary, pancreas, parathyroid
• B. Thyroid, parathyroid, adrenal
• C. Pancreas, liver, spleen
• D. Pituitary, thyroid, adrenal

Answer: (A)

MEN1 is a hereditary tumor syndrome caused by mutations in the MEN1 gene, which encodes the tumor suppressor menin. Loss of menin function predisposes to tumors in a characteristic set of endocrine tissues: the parathyroid glands, the pituitary, and the pancreatic islet cells. This trio—parathyroid hyperplasia or adenomas, pituitary adenomas (often prolactin- or growth hormone-secreting), and pancreatic neuroendocrine tumors—is the hallmark pattern seen in MEN1. The reason this option is the best match is that these glands are classically involved due to the menin-related tumor-suppressor dysfunction, whereas glands listed in other options are not part of the typical MEN1 spectrum (some belong to other syndromes like MEN2 or are not endocrine targets in MEN1).

MEN1 is a hereditary tumor syndrome caused by mutations in the MEN1 gene, which encodes the tumor suppressor menin. Loss of menin function predisposes to tumors in a characteristic set of endocrine tissues: the parathyroid glands, the pituitary, and the pancreatic islet cells. This trio—parathyroid hyperplasia or adenomas, pituitary adenomas (often prolactin- or growth hormone-secreting), and pancreatic neuroendocrine tumors—is the hallmark pattern seen in MEN1. The reason this option is the best match is that these glands are classically involved due to the menin-related tumor-suppressor dysfunction, whereas glands listed in other options are not part of the typical MEN1 spectrum (some belong to other syndromes like MEN2 or are not endocrine targets in MEN1).